EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma

Runping Fang; Xin Chen; Sicong Zhang; Hui Shi; Youqiong Ye; Hailing Shi; Zhongyu Zou; Peng Li; Qing Guo; Li Ma; Chuan He; Suyun Huang

doi:10.1038/s41467-020-20379-7

Nature Communications (Jan 2021)

EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma

Runping Fang,
Xin Chen,
Sicong Zhang,
Hui Shi,
Youqiong Ye,
Hailing Shi,
Zhongyu Zou,
Peng Li,
Qing Guo,
Li Ma,
Chuan He,
Suyun Huang

Affiliations

Runping Fang: Department of Human and Molecular Genetics, Institute of Molecular Medicine, Massey Cancer Center, Virginia Commonwealth University, School of Medicine
Xin Chen: Department of Neurosurgery, The University of Texas MD Anderson Cancer Center
Sicong Zhang: Department of Neurosurgery, The University of Texas MD Anderson Cancer Center
Hui Shi: Department of Human and Molecular Genetics, Institute of Molecular Medicine, Massey Cancer Center, Virginia Commonwealth University, School of Medicine
Youqiong Ye: Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School
Hailing Shi: Department of Chemistry, The University of Chicago
Zhongyu Zou: Department of Chemistry, The University of Chicago
Peng Li: Department of Human and Molecular Genetics, Institute of Molecular Medicine, Massey Cancer Center, Virginia Commonwealth University, School of Medicine
Qing Guo: Department of Neurosurgery, The University of Texas MD Anderson Cancer Center
Li Ma: Department of Neurosurgery, The University of Texas MD Anderson Cancer Center
Chuan He: Department of Chemistry, The University of Chicago
Suyun Huang: Department of Human and Molecular Genetics, Institute of Molecular Medicine, Massey Cancer Center, Virginia Commonwealth University, School of Medicine

DOI: https://doi.org/10.1038/s41467-020-20379-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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EGFR is frequently constitutively active in glioblastoma (GBM). Here, the authors show that EGFR induces YTHDF2 protein stabilization, which reduces cholesterol homeostasis through an RNA m6A methylation dependent molecular mechanism to promote GBM tumourigenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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