Bihdād (Oct 2020)
Investigation and Determination of Osvix by Gold Nanorods by Spectrophotometry
Abstract
Background and Aims: Osvix drug is an internal brand of Plavix, which is used to prevent blood coagulation in many heart diseases. The aim of the present study was to measure this drug by gold nanorods in optimum conditions and in real samples. Material and Methods: Gold nanorods were synthesized by the seeded-mediated method. Measurement of Osvix drug by gold nanorods was performed by optimizing important factors at a maximum wavelength of 650 nm. The concentration of annoying agents and the effect of electrolyte were investigated . Results: The optimum values were calculated using a Visible-Ultraviolet spectrophotometer at 650 nm for factors of pH=8, nanoparticles volume of 1 mL, buffer volume of 2.5 mL and residence time of 40 seconds, As well as the type of buffer, phosphate was obtained. The calibration curve was linear in the concentration range of 0.2 - 10 ppm. Drug concentration was measured in real samples. Conclusion: The limit of detection and limit of quantification were 0.206 and 0.687 ppm, respectively. This method , which is rapid and simple, with high Precision and reproducibility and appropriate limit of detection , a desirable suggested method is for measuring of Osvix drug .
