Terminator-free template-independent enzymatic DNA synthesis for digital information storage

Henry H. Lee; Reza Kalhor; Naveen Goela; Jean Bolot; George M. Church

doi:10.1038/s41467-019-10258-1

Nature Communications (Jun 2019)

Terminator-free template-independent enzymatic DNA synthesis for digital information storage

Henry H. Lee,
Reza Kalhor,
Naveen Goela,
Jean Bolot,
George M. Church

Affiliations

Henry H. Lee: Department of Genetics, Harvard Medical School
Reza Kalhor: Department of Genetics, Harvard Medical School
Naveen Goela: Technicolor Research & Innovation Lab
Jean Bolot: Technicolor Research & Innovation Lab
George M. Church: Department of Genetics, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-019-10258-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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Adoption of DNA as a data storage medium could be accelerated with specialized synthesis processes and codecs. The authors describe TdT-mediated DNA synthesis in which data is stored in transitions between non-identical nucleotides and the use of synchronization markers to provide error tolerance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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