Nature Communications (Sep 2018)
ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes
- Juncheng Wei,
- Yanzhi Yuan,
- Lu Chen,
- Yuanming Xu,
- Yuehui Zhang,
- Yajun Wang,
- Yanjie Yang,
- Clara Bien Peek,
- Lauren Diebold,
- Yi Yang,
- Beixue Gao,
- Chaozhi Jin,
- Johanna Melo-Cardenas,
- Navdeep S. Chandel,
- Donna D. Zhang,
- Hui Pan,
- Kezhong Zhang,
- Jian Wang,
- Fuchu He,
- Deyu Fang
Affiliations
- Juncheng Wei
- Department of Pathology, Northwestern University Feinberg School of Medicine
- Yanzhi Yuan
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics
- Lu Chen
- Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science
- Yuanming Xu
- Department of Pathology, Northwestern University Feinberg School of Medicine
- Yuehui Zhang
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics
- Yajun Wang
- Department of Pathology, Northwestern University Feinberg School of Medicine
- Yanjie Yang
- Department of Medical Psychology, Public Health Institute of Harbin Medical University
- Clara Bien Peek
- Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine
- Lauren Diebold
- Department of Medicine, Northwestern University Feinberg School of Mdicine
- Yi Yang
- Department of Pathology, Northwestern University Feinberg School of Medicine
- Beixue Gao
- Department of Pathology, Northwestern University Feinberg School of Medicine
- Chaozhi Jin
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics
- Johanna Melo-Cardenas
- Department of Pathology, Northwestern University Feinberg School of Medicine
- Navdeep S. Chandel
- Department of Medicine, Northwestern University Feinberg School of Mdicine
- Donna D. Zhang
- Department of Pharmacology and Toxicology, University of Arizona
- Hui Pan
- Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science
- Kezhong Zhang
- Center for Molecular Medicine and Genetics, Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine
- Jian Wang
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics
- Fuchu He
- State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics
- Deyu Fang
- Department of Pathology, Northwestern University Feinberg School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-06091-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
HRD1 is an E3 ligase known to play a role in targeting degradation of misfolded proteins in the ER. Here the authors show that HRD1 interacts with metabolic enzymes and its liver specific deficiency results in lower body weight, blood glucose and plasma lipids during high fat diet in mice.
