FRQ-CK1 interaction determines the period of circadian rhythms in Neurospora

Xiao Liu; Ahai Chen; Angélica Caicedo-Casso; Guofei Cui; Mingjian Du; Qun He; Sookkyung Lim; Hang J. Kim; Christian I. Hong; Yi Liu

doi:10.1038/s41467-019-12239-w

Nature Communications (Sep 2019)

FRQ-CK1 interaction determines the period of circadian rhythms in Neurospora

Xiao Liu,
Ahai Chen,
Angélica Caicedo-Casso,
Guofei Cui,
Mingjian Du,
Qun He,
Sookkyung Lim,
Hang J. Kim,
Christian I. Hong,
Yi Liu

Affiliations

Xiao Liu: Department of Physiology, University of Texas Southwestern Medical Center
Ahai Chen: Department of Physiology, University of Texas Southwestern Medical Center
Angélica Caicedo-Casso: Department of Mathematics, Universidad del Valle
Guofei Cui: State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University
Mingjian Du: Department of Physiology, University of Texas Southwestern Medical Center
Qun He: State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University
Sookkyung Lim: Department of Mathematical Sciences, University of Cincinnati
Hang J. Kim: Division of Statistics and Data Science, University of Cincinnati
Christian I. Hong: Department of Pharmacology and Systems Physiology, University of Cincinnati
Yi Liu: Department of Physiology, University of Texas Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-019-12239-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Circadian clocks control daily rhythms of molecular and physiological activities. Here, the authors show that the interaction between proteins FRQ and CK1, rather than FRQ stability, is a major rate-limiting step in circadian period determination in the model fungus Neurospora.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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