A cysteine-based molecular code informs collagen C-propeptide assembly

Andrew S. DiChiara; Rasia C. Li; Patreece H. Suen; Azade S. Hosseini; Rebecca J. Taylor; Alexander F. Weickhardt; Diya Malhotra; Darrell R. McCaslin; Matthew D. Shoulders

doi:10.1038/s41467-018-06185-2

Nature Communications (Oct 2018)

A cysteine-based molecular code informs collagen C-propeptide assembly

Andrew S. DiChiara,
Rasia C. Li,
Patreece H. Suen,
Azade S. Hosseini,
Rebecca J. Taylor,
Alexander F. Weickhardt,
Diya Malhotra,
Darrell R. McCaslin,
Matthew D. Shoulders

Affiliations

Andrew S. DiChiara: Department of Chemistry, Massachusetts Institute of Technology
Rasia C. Li: Department of Chemistry, Massachusetts Institute of Technology
Patreece H. Suen: Department of Chemistry, Massachusetts Institute of Technology
Azade S. Hosseini: Department of Chemistry, Massachusetts Institute of Technology
Rebecca J. Taylor: Department of Chemistry, Massachusetts Institute of Technology
Alexander F. Weickhardt: Department of Chemistry, Massachusetts Institute of Technology
Diya Malhotra: Department of Chemistry, Massachusetts Institute of Technology
Darrell R. McCaslin: Department of Biochemistry, University of Wisconsin
Matthew D. Shoulders: Department of Chemistry, Massachusetts Institute of Technology

DOI: https://doi.org/10.1038/s41467-018-06185-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Collagen proteins assemble into trimers from distinct monomers with high specificity, yet the molecular basis for this specificity remains unclear. Here the authors demonstrate the crucial role of conserved C-terminal domain cysteine residues and calcium in homotrimeric procollagen assembly.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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