Frontiers in Chemistry (Aug 2018)
Chiral 1H NMR of Atropisomeric Quinazolinones With Enantiopure Phosphoric Acids
Abstract
A chiral phosphoric acid promoted enantioselective NMR analysis of atropisomeric quinazolinones was described, in which a variety of racemic arylquinazolinones such as afloqualone and IC-87114 were well recognized with up to 0. 21 ppm ΔΔδ value. With this method, the optical purities of different non-racemic substrates can be fast evaluated with high accuracy.
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