Nature Communications (Jan 2020)

Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation

  • Matthew R. King,
  • Sabine Petry

DOI
https://doi.org/10.1038/s41467-019-14087-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

Read online

The microtubule binding protein TPX2 enhances branching microtubule nucleation though the current mechanisms are unclear. Here, the authors show that TPX2 undergoes liquid-liquid phase separation and co-condensates with tubulin to enhance TPX2-mediated microtubule nucleation.