Ni-catalyzed regio- and stereo-defined intermolecular cross-electrophile dialkylation of alkynes without directing group

Abstract

The synthesis of regio- and stereo-defined alkenes with multiple alkyl substituents is an unmet challenge. Here, the authors report a nickel-catalyzed intermolecular cross-dialkylation of alkynes devoid of directing or activating groups to afford multiple aliphatic substituted alkenes in a syn-selective fashion.