Cancer Management and Research (Jul 2021)

Efficacy and Safety Aiming at the Combined-Modality Therapy of External Beam Radiotherapy (40Gy) and Iodine-125 Seed Implantation for Locally Advanced NSCLC in the Elderly

  • Tian LJ,
  • Liu HZ,
  • Zhang Q,
  • Geng DZ,
  • Huo YQ,
  • Xu SJ,
  • Hao Y

Journal volume & issue
Vol. Volume 13
pp. 5457 – 5466

Abstract

Read online

Li-Jun Tian,1,* Hong-Zhi Liu,2,* Qiang Zhang,1 Dian-Zhong Geng,1 Yu-Qing Huo,1 Shou-Jian Xu,1 Yan-Zhang Hao1 1Department of Oncology, Binzhou Medical University Hospital, Binzhou, Shandong, People’s Republic of China; 2Department of Orthopedics, Binzhou Medical University Hospital, Binzhou, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan-Zhang Hao HuangHe Two Road, Binzhou, 256603 Tel +8615506308710Fax +86 (0)543-3257792Email [email protected]: To evaluate the efficacy and safety of combined-modality therapy for elderly patients with locally advanced non-small-cell lung cancer (NSCLC) invading the chest wall.Patients and Methods: We retrospectively enrolled 21 elderly patients (aged ≥ 60 years) with locally advanced NSCLC invading the chest wall. For external beam radiotherapy (EBRT) of the primary tumor, 40Gy was applied and supplemented with iodine-125 seed implantation while 60Gy was applied to the lymph nodes of the mediastinum. Follow-up was conducted every 3 months postoperatively. The related analytic parameters were change in tumor size, the objective response rate (ORR), the disease control rate (DCR), the degree of pain relief, the improvement of physical status, and toxicity.Results: The combined-modality therapy significantly inhibited local growth of the tumor (from 7.84± 1.20 to 4.69± 1.90 cm) (P < 0.0001), with 71.4% ORR and 90.5% DCR at 1 year. The cancer-related pain was significantly relieved (P < 0.05) and physical status was significantly improved (P < 0.05). No procedure-associated death or grade > 2 irradiation-related adverse effects were reported in this study.Conclusion: The combined-modality therapy of EBRT with 40Gy and permanent iodine-125 seed implantation is an efficacious and safe treatment option for elderly patients with locally advanced NSCLC invading the chest wall.Keywords: iodine-125 seed implantation, external beam radiotherapy, combined therapy, NSCLC, elderly

Keywords