CD11a regulates hematopoietic stem and progenitor cells

Lifei Hou; Lifei Hou; Lifei Hou; Lifei Hou; Koichi Yuki; Koichi Yuki; Koichi Yuki; Koichi Yuki

doi:10.3389/fimmu.2023.1219953

Frontiers in Immunology (Sep 2023)

CD11a regulates hematopoietic stem and progenitor cells

Lifei Hou,
Lifei Hou,
Lifei Hou,
Lifei Hou,
Koichi Yuki,
Koichi Yuki,
Koichi Yuki,
Koichi Yuki

Affiliations

Lifei Hou: Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Division, Boston Children’s Hospital, Boston, MA, United States
Lifei Hou: Department of Anaesthesia, Harvard Medical School, Boston, MA, United States
Lifei Hou: Department of Immunology, Harvard Medical School, Boston, MA, United States
Lifei Hou: Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, United States
Koichi Yuki: Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Division, Boston Children’s Hospital, Boston, MA, United States
Koichi Yuki: Department of Anaesthesia, Harvard Medical School, Boston, MA, United States
Koichi Yuki: Department of Immunology, Harvard Medical School, Boston, MA, United States
Koichi Yuki: Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, United States

DOI: https://doi.org/10.3389/fimmu.2023.1219953
Journal volume & issue: Vol. 14

Abstract

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Integrin αLβ2 (CD11a/CD18, CD11a) is a critical leukocyte adhesion molecule in leukocyte arrest and immunological synapse formation. However, its role in the bone marrow has not been investigated in depth. Here we showed that CD11a was expressed on all subsets of hematopoietic stem and progenitor cells (HPSCs). CD11a deficiency enhanced HSPCs activity under lipopolysaccharide (LPS) stimulation as demonstrated by a higher HSPC cell count along with an increase in cell proliferation. However, our mixed chimera experiment did not support that this phenotype was driven in a cell-intrinsic manner. Rather we found that the production of IL-27, a major cytokine that drives HSPC proliferation, was significantly upregulated both in vivo and in vitro. This adds a novel role of CD11a biology.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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