Biomedicines (Feb 2023)

Synchronous Breast and Cervical Carcinoma: A Genetic Point of View

  • Maya Mazuwin Yahya,
  • Mohd Pazudin Ismail,
  • Shogeta Ramanathan,
  • Muhammad Nashriq Kadir,
  • Azzahra Azhar,
  • Noorul Balqis Che Ibrahim,
  • Chee Lee Wee,
  • Zahiah Mohd Amin,
  • Seng Kong Tham,
  • Shuhaila Mat-Sharani,
  • Nik Soriani Yaacob

DOI
https://doi.org/10.3390/biomedicines11020525
Journal volume & issue
Vol. 11, no. 2
p. 525

Abstract

Read online

Breast carcinoma is the most common cancer of women in Malaysia. The most common sites of metastasis are the lung, liver, bone and brain. A 45-year-old lady was diagnosed with left invasive breast carcinoma stage IV (T4cN1M1) with axillary lymph nodes and lung metastasis. She was noted to have a cervical mass through imaging, and biopsy showed CIN III. Post chemotherapy, the patient underwent left simple mastectomy with examination under anaesthesia of the cervix, cystoscopy and staging. The cervical histopathological examination (HPE) showed squamous cell carcinoma, and clinical staging was 2A. The breast tissue HPE showed invasive carcinoma with triple receptors positivity. The patient was given tamoxifen and put on concurrent chemoradiotherapy (CCRT) for the cervical cancer. The management of each pathology of this patient involved a multi-disciplinary team that included surgeons, oncologists, gynaecologists, pathologists and radiologists. Due to the complexity of the case with two concurrent cancers, the gene expression profiles may help predict the patient’s clinical outcome.

Keywords