Synchronous Breast and Cervical Carcinoma: A Genetic Point of View
Maya Mazuwin Yahya,
Mohd Pazudin Ismail,
Shogeta Ramanathan,
Muhammad Nashriq Kadir,
Azzahra Azhar,
Noorul Balqis Che Ibrahim,
Chee Lee Wee,
Zahiah Mohd Amin,
Seng Kong Tham,
Shuhaila Mat-Sharani,
Nik Soriani Yaacob
Affiliations
Maya Mazuwin Yahya
Department of Surgery, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
Mohd Pazudin Ismail
Department of Obstetrics and Gynaecology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
Shogeta Ramanathan
Department of Surgery, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
Muhammad Nashriq Kadir
Department of Obstetrics and Gynaecology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
Azzahra Azhar
Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
Noorul Balqis Che Ibrahim
Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
Chee Lee Wee
Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
Zahiah Mohd Amin
MyGenome Sdn Berhad, Kuala Lumpur 50400, Selangor, Malaysia
Seng Kong Tham
MyGenome Sdn Berhad, Kuala Lumpur 50400, Selangor, Malaysia
Shuhaila Mat-Sharani
Biomedicine Program, School of Health Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
Nik Soriani Yaacob
Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia
Breast carcinoma is the most common cancer of women in Malaysia. The most common sites of metastasis are the lung, liver, bone and brain. A 45-year-old lady was diagnosed with left invasive breast carcinoma stage IV (T4cN1M1) with axillary lymph nodes and lung metastasis. She was noted to have a cervical mass through imaging, and biopsy showed CIN III. Post chemotherapy, the patient underwent left simple mastectomy with examination under anaesthesia of the cervix, cystoscopy and staging. The cervical histopathological examination (HPE) showed squamous cell carcinoma, and clinical staging was 2A. The breast tissue HPE showed invasive carcinoma with triple receptors positivity. The patient was given tamoxifen and put on concurrent chemoradiotherapy (CCRT) for the cervical cancer. The management of each pathology of this patient involved a multi-disciplinary team that included surgeons, oncologists, gynaecologists, pathologists and radiologists. Due to the complexity of the case with two concurrent cancers, the gene expression profiles may help predict the patient’s clinical outcome.
