Integrated chromatin accessibility and DNA methylation analysis to reveal the critical epigenetic modification and regulatory mechanism in gonadal differentiation of the sequentially hermaphroditic fish, Monopterus albus

Abstract

Highlights DNA methylation modification plays a more crucial role than chromatin accessibility in gonad development. DNA methylation in the transcription start site plays a key role in gonad development. DNA methylation of the plastin-2 promoter inhibited gene expression. Plastin-2 is positively regulated by dmrt1 while negatively regulated by foxl2.

Keywords

• Sex reversal
• Monopterus albus
• DNA methylation
• Chromatin accessibility
• Epigenetic modification