Nature Communications (Nov 2019)

SERS discrimination of single DNA bases in single oligonucleotides by electro-plasmonic trapping

  • Jian-An Huang,
  • Mansoureh Z. Mousavi,
  • Yingqi Zhao,
  • Aliaksandr Hubarevich,
  • Fatima Omeis,
  • Giorgia Giovannini,
  • Moritz Schütte,
  • Denis Garoli,
  • Francesco De Angelis

DOI
https://doi.org/10.1038/s41467-019-13242-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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Sensing DNA bases by surface-enhanced Raman spectroscopy (SERS) in plasmonic nanopores has suffered from rapid flow through of molecules. Here, the authors attach DNA molecules to gold nanoparticles which, due to electro-plasmonic trapping, allow for controlled residence times and discrimination of single nucleotides.