Endothelin-1 Gene Polymorphisms rs5370, rs1476046, and rs3087459 are not Associated with Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus
Šeruga Maja,
Kariž Stojan,
Makuc Jana,
Završnik Matej,
Cilenšek Ines,
Gazdikova Katarina,
Caprnda Martin,
Kruzliak Peter,
Petrovič Daniel
Affiliations
Šeruga Maja
Department of Internal Medicine, General Hospital Murska Sobota, Murska Sobota, Slovenia
Kariž Stojan
Department of Internal Medicine, General Hospital Izola, Izola, Slovenia
Makuc Jana
Department of Internal Medicine, General Hospital Slovenj Gradec, Slovenj Gradec, Slovenia
Završnik Matej
University Medical Centre Maribor, Clinic of Internal Medicine, Department of Diabetes and Metabolic Diseases, Maribor, Slovenia
Cilenšek Ines
Institute of Histology and Embryology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Gazdikova Katarina
Department of General Medicine, Faculty of Medicine, Slovak Medical University, Bratislava, Slovak Republic
Caprnda Martin
First Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia
Kruzliak Peter
Laboratory of Structural Biology and Proteomics, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
Petrovič Daniel
Institute of Histology and Embryology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Background: Diabetic nephropathy (DN) is a major microvascular complication of type 2 diabetes mellitus (T2DM). Several lines of evidence implicate the endothelin (ET) system in the pathophysiology of DN. The aim of the present study was to analyze if genetic polymorphisms of the ET-1 (EDN1) gene affect susceptibility to DN in Caucasians with T2DM.
