Nature Communications (Oct 2016)

Fhf2 gene deletion causes temperature-sensitive cardiac conduction failure

  • David S. Park,
  • Akshay Shekhar,
  • Christopher Marra,
  • Xianming Lin,
  • Carolina Vasquez,
  • Sergio Solinas,
  • Kevin Kelley,
  • Gregory Morley,
  • Mitchell Goldfarb,
  • Glenn I. Fishman

DOI
https://doi.org/10.1038/ncomms12966
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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Fever is a defence mechanism against infection, but it may also cause abnormal heart rhythm viaunknown mechanism. Here the authors identify FHF2 protein as a key regulator of myocardial excitability that protects the heart against conduction failure in response to an increase in body temperature.