Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration

Hasini Jayatilaka; Pranay Tyle; Jonathan J. Chen; Minsuk Kwak; Julia Ju; Hyun Ji Kim; Jerry S. H. Lee; Pei-Hsun Wu; Daniele M. Gilkes; Rong Fan; Denis Wirtz

doi:10.1038/ncomms15584

Nature Communications (May 2017)

Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration

Hasini Jayatilaka,
Pranay Tyle,
Jonathan J. Chen,
Minsuk Kwak,
Julia Ju,
Hyun Ji Kim,
Jerry S. H. Lee,
Pei-Hsun Wu,
Daniele M. Gilkes,
Rong Fan,
Denis Wirtz

Affiliations

Hasini Jayatilaka: Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
Pranay Tyle: Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
Jonathan J. Chen: Department of Biomedical Engineering, Yale University
Minsuk Kwak: Department of Biomedical Engineering, Yale University
Julia Ju: Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
Hyun Ji Kim: Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
Jerry S. H. Lee: Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
Pei-Hsun Wu: Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
Daniele M. Gilkes: Department of Chemical and Biomolecular Engineering, The Johns Hopkins University
Rong Fan: Department of Biomedical Engineering, Yale University
Denis Wirtz: Department of Chemical and Biomolecular Engineering, The Johns Hopkins University

DOI: https://doi.org/10.1038/ncomms15584
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Tumor cell proliferation and migration, key drivers of metastasis, can be mechanistically coupled in matrix embedded human sarcoma and carcinoma cells through cell density via a synergistic, paracrine signaling mechanism between Interleukins 6/8. Inhibition of this mechanism significantly decreases metastasis in mouse xenograft models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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