Gut microbiome mediates the protective effects of exercise after myocardial infarction
Qiulian Zhou,
Jiali Deng,
Xue Pan,
Danni Meng,
Yujiao Zhu,
Yuzheng Bai,
Chao Shi,
Yi Duan,
Tianhui Wang,
Xinli Li,
Joost PG Sluijter,
Junjie Xiao
Affiliations
Qiulian Zhou
Institute of Geriatrics (Shanghai University), (The Sixth People’s Hospital of Nantong), School of Medicine, Affiliated Nantong Hospital of Shanghai University, Shanghai University
Jiali Deng
Cardiac Regeneration and Ageing Lab, School of Life Science, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, Shanghai University
Xue Pan
Institute of Geriatrics (Shanghai University), (The Sixth People’s Hospital of Nantong), School of Medicine, Affiliated Nantong Hospital of Shanghai University, Shanghai University
Danni Meng
Institute of Geriatrics (Shanghai University), (The Sixth People’s Hospital of Nantong), School of Medicine, Affiliated Nantong Hospital of Shanghai University, Shanghai University
Yujiao Zhu
Institute of Geriatrics (Shanghai University), (The Sixth People’s Hospital of Nantong), School of Medicine, Affiliated Nantong Hospital of Shanghai University, Shanghai University
Yuzheng Bai
Cardiac Regeneration and Ageing Lab, School of Life Science, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, Shanghai University
Chao Shi
Cardiac Regeneration and Ageing Lab, School of Life Science, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, Shanghai University
Yi Duan
Cardiac Regeneration and Ageing Lab, School of Life Science, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, Shanghai University
Tianhui Wang
Cardiac Regeneration and Ageing Lab, School of Life Science, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, Shanghai University
Xinli Li
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
Joost PG Sluijter
Department of Cardiology, Laboratory of Experimental Cardiology, University Utrecht, University Medical Center Utrecht
Junjie Xiao
Institute of Geriatrics (Shanghai University), (The Sixth People’s Hospital of Nantong), School of Medicine, Affiliated Nantong Hospital of Shanghai University, Shanghai University
Abstract Background Gut microbiota plays important roles in health maintenance and diseases. Physical exercise has been demonstrated to be able to modulate gut microbiota. However, the potential role of gut microbiome in exercise protection to myocardial infarction (MI) remains unclear. Results Here, we discovered exercise training ameliorated cardiac dysfunction and changed gut microbial richness and community structure post-MI. Moreover, gut microbiota pre-depletion abolished the protective effects of exercise training in MI mice. Furthermore, mice receiving microbiota transplants from exercised MI mice had better cardiac function compared to mice receiving microbiota transplants from non-exercised MI mice. Mechanistically, we analyzed metabolomics in fecal samples from exercised mice post-MI and identified 3-Hydroxyphenylacetic acid (3-HPA) and 4-Hydroxybenzoic acid (4-HBA), which could be applied individually to protect cardiac dysfunction post-MI and apoptosis through NRF2. Conclusions Together, our study provides new insights into the role of gut microbiome in exercise protection to MI, offers opportunities to modulate cardiovascular diseases by exercise, microbiome and gut microbiota-derived 3-HPA and 4-HBA. Video Abstract
