Nature Communications (Mar 2021)
A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons
Abstract
SFPQ is a splicing factor and its mutations are associated to amyotrophic lateral sclerosis (ALS) patients. Here, the authors show that SFPQ represses the use of pathogenic cryptic last exons in zebrafish, mouse and human cells.