Nature Communications (Jul 2022)
Vibrio cholerae O139 genomes provide a clue to why it may have failed to usher in the eighth cholera pandemic
- Thandavarayan Ramamurthy,
- Agila Kumari Pragasam,
- Alyce Taylor-Brown,
- Robert C. Will,
- Karthick Vasudevan,
- Bhabatosh Das,
- Sunil Kumar Srivastava,
- Goutam Chowdhury,
- Asish K. Mukhopadhyay,
- Shanta Dutta,
- Balaji Veeraraghavan,
- Nicholas R. Thomson,
- Naresh C. Sharma,
- Gopinath Balakrish Nair,
- Yoshifumi Takeda,
- Amit Ghosh,
- Gordon Dougan,
- Ankur Mutreja
Affiliations
- Thandavarayan Ramamurthy
- National Institute of Cholera and Enteric Diseases (NICED)
- Agila Kumari Pragasam
- Department of Clinical Microbiology, Christian Medical College
- Alyce Taylor-Brown
- Parasites & Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus
- Robert C. Will
- Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge
- Karthick Vasudevan
- Department of Clinical Microbiology, Christian Medical College
- Bhabatosh Das
- Translational Health Science and Technology Institute
- Sunil Kumar Srivastava
- Swami Shraddhanand College, University of Delhi
- Goutam Chowdhury
- National Institute of Cholera and Enteric Diseases (NICED)
- Asish K. Mukhopadhyay
- National Institute of Cholera and Enteric Diseases (NICED)
- Shanta Dutta
- National Institute of Cholera and Enteric Diseases (NICED)
- Balaji Veeraraghavan
- Department of Clinical Microbiology, Christian Medical College
- Nicholas R. Thomson
- Parasites & Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus
- Naresh C. Sharma
- Maharishi Valmiki Infectious Diseases Hospital
- Gopinath Balakrish Nair
- Rajiv Gandhi Centre for Biotechnology
- Yoshifumi Takeda
- National Institute of Infectious Diseases
- Amit Ghosh
- National Institute of Cholera and Enteric Diseases (NICED)
- Gordon Dougan
- Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge
- Ankur Mutreja
- Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-022-31391-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 10
Abstract
The O139 Vibrio cholerae serogroup emerged in the 1990s and spread rapidly but did not become globally dominant. Here, the authors describe the genomic epidemiology of this strain and identify changes in virulence and antimicrobial resistance characteristics that they hypothesise may have contributed to its decline.
