Decursinol Angelate Arrest Melanoma Cell Proliferation by Initiating Cell Death and Tumor Shrinkage via Induction of Apoptosis

Abstract

Melanoma is known to aggressively metastasize and is one of the prominent causes of skin cancer mortality. This study was designed to assess the molecular mechanism of decursinol angelate (DA) against murine melanoma cell line (B16F10 cells). Treatment of DA resulted in growth inhibition and cell cycle arrest at G0/G1 (p p p p p p p p p p p p p p p p > 0.010) and cleaved caspase-3 (p p p p p p p < 0.0001). In summary, our study revealed that DA is an effective treatment against B16F10 melanoma cells and xenograft mice model.

Keywords

• B16F10 murine melanoma cells
• decursinol angelate (DA)
• reactive oxygen species (ROS)
• apoptosis
• cell cycle