Frontiers in Oncology (Oct 2014)

Stereotactic Body Radiotherapy as Primary Therapy for Head and Neck Cancer in the Elderly or Patients with Poor Performance

  • Arya eAmini,
  • Jessica D McDermott,
  • Gregory eGan,
  • Shilpa eBhatia,
  • Whitney eSumner,
  • Christine eFisher,
  • Antonio eJimeno,
  • Daniel W Bowles,
  • David eRaben,
  • Sana eKaram

DOI
https://doi.org/10.3389/fonc.2014.00274
Journal volume & issue
Vol. 4

Abstract

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Objective: Stereotactic Body Radiotherapy (SBRT) is increasingly used to treat a variety of tumors, including head and neck squamous cell carcinomas (HNSCC) in the recurrent setting. While there are published data for re-irradiation using SBRT for HNSCC, there are limited data supporting its use as upfront treatment for locally advanced disease.Study Design/Methods: Here we describe three patients who received SBRT as the primary treatment for their HNSCC along with a review of the current literature and discussion of future pathways.Results: The three cases discussed tolerated treatment well with manageable acute toxicities and had either a clinical or radiographic complete response to therapy.Conclusions: HNSCC presents a unique challenge in the elderly, where medical comorbidities make it difficult to tolerate conventional radiation, often given with a systemic sensitizer. For these individuals, providing a shortened course using SBRT may offer an effective alternative.

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