Tumor-induced osteomalacia – a mystery illness beyond aches, pains, and depression

Abstract

Objective. Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by chronic hypophosphatemia and osteomalacia. We present case of a patient with a protracted clinical course of TIO. TIO profoundly affected every aspect of his life with subsequent profound physical and psychosocial disabilities.

Keywords

• tumor-induced osteomalacia
• oncogenic osteomalacia
• paraneoplastic hypophosphatemia
• mesenchymal tumor
• phosphatonin
• fibroblast growth factor-23