Annals of Clinical and Translational Neurology (Aug 2021)
DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France
- Maria Pia Sormani,
- Marco Salvetti,
- Pierre Labauge,
- Irene Schiavetti,
- Helene Zephir,
- Luca Carmisciano,
- Caroline Bensa,
- Nicola De Rossi,
- Jean Pelletier,
- Cinzia Cordioli,
- Sandra Vukusic,
- Lucia Moiola,
- Philippe Kerschen,
- Marta Radaelli,
- Marie Théaudin,
- Paolo Immovilli,
- Olivier Casez,
- Marco Capobianco,
- Jonathan Ciron,
- Maria Trojano,
- Bruno Stankoff,
- Alain Créange,
- Gioacchino Tedeschi,
- Pierre Clavelou,
- Giancarlo Comi,
- Eric Thouvenot,
- Mario Alberto Battaglia,
- Thibault Moreau,
- Francesco Patti,
- Jérôme De Sèze,
- Celine Louapre,
- the Musc‐19,
- the Covisep study groups
Affiliations
- Maria Pia Sormani
- Department of Health Sciences University of Genova Genova Italy
- Marco Salvetti
- Department of Neuroscience Mental Health and Sensory Organs Sapienza University of Rome Rome Italy
- Pierre Labauge
- Department of Neurology CHU de Montpellier Montpellier France
- Irene Schiavetti
- Department of Health Sciences University of Genova Genova Italy
- Helene Zephir
- Department of Neurology U 1172 CRC‐SEP University Hospital of Lille Lille France
- Luca Carmisciano
- Department of Health Sciences University of Genova Genova Italy
- Caroline Bensa
- Department of Neurology Hôpital Fondation Adolphe de Rothschild Paris France
- Nicola De Rossi
- Centro Sclerosi Multipla ASST Spedali Civili di Brescia Montichiari Italy
- Jean Pelletier
- Department of Neurology Aix Marseille Univ APHM, Hôpital de la Timone Pôle de Neurosciences Cliniques Marseille 13005 France
- Cinzia Cordioli
- Centro Sclerosi Multipla ASST Spedali Civili di Brescia Montichiari Italy
- Sandra Vukusic
- Service de Neurologie, sclérose en plaques, pathologies de la myéline et neuro‐inflammation Hospices Civils de Lyon Hôpital Neurologique Bron France
- Lucia Moiola
- Department of Neurology Multiple Sclerosis Center IRCCS Ospedale San Raffaele Milan Italy
- Philippe Kerschen
- Centre Hospitalier de Luxembourg Luxembourg City Luxembourg
- Marta Radaelli
- Department of Neurology and Multiple Sclerosis Center ASST “Papa Giovanni XXIII” Bergamo Italy
- Marie Théaudin
- Division of Neurology Department of Clinical Neurosciences Lausanne University Hospital and University of Lausanne Lausanne Switzerland
- Paolo Immovilli
- Multiple Sclerosis Center Ospedale Guglielmo da Saliceto Piacenza Italy
- Olivier Casez
- Department of Neurology University Hospital Grenoble Alpes Neuro Inflammatory Unit Grenoble France
- Marco Capobianco
- Department of Neurology Regional Referral Multiple Sclerosis Centre University Hospital San Luigi Orbassano (Torino) Italy
- Jonathan Ciron
- Department of Neurology CHU de Toulouse CRC‐SEP Toulouse France
- Maria Trojano
- Department of Basic Medical Sciences Neurosciences and Sense Organs University of Bari Bari Italy
- Bruno Stankoff
- Sorbonne University Paris Brain Institute ICM Pitié Salpêtrière Hospital Inserm UMR S 1127 CNRS UMR 7225 Paris France
- Alain Créange
- Service de Neurologie and CRC SEP APHP Groupe Hospitalier Henri Mondor UPEC Université Créteil France
- Gioacchino Tedeschi
- Department of Advanced Medical and Surgical Sciences University of Campania Napoli Italy
- Pierre Clavelou
- University of Clermont Auvergne CHU de Clermont‐Ferrand Inserm Neuro‐Dol Clermont‐Ferrand France
- Giancarlo Comi
- Institute of Experimental Neurology IRCCS Ospedale San Raffaele Milano Italy
- Eric Thouvenot
- Department of Neurology Nîmes University Hospital Nîmes France
- Mario Alberto Battaglia
- Research Department Italian Multiple Sclerosis Foundation Genoa Italy
- Thibault Moreau
- Department of Neurology University hospital of Dijon EA4184 Dijon France
- Francesco Patti
- Department of Medical and Surgical Sciences and Advanced Technologies GF Ingrassia University of Catania Catania Italy
- Jérôme De Sèze
- Department of Neurology CIC INSERM 1434 CHU de Strasbourg Strasbourg France
- Celine Louapre
- Sorbonne University Paris Brain Institute ICM, Assistance Publique Hôpitaux de Paris APHP Hôpital de la Pitié‐Salpêtrière Inserm CNRS CIC Neuroscience Paris France
- the Musc‐19
- the Covisep study groups
- DOI
- https://doi.org/10.1002/acn3.51408
- Journal volume & issue
-
Vol. 8,
no. 8
pp. 1738 – 1744
Abstract
Abstract We evaluated the effect of DMTs on Covid‐19 severity in patients with MS, with a pooled‐analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid‐19 severity was assessed by multivariate ordinal‐logistic models and pooled by a fixed‐effect meta‐analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti‐CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p < 0.001) with Covid‐19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, p = 0.047). This pooled‐analysis confirms an increased risk of severe Covid‐19 in patients on anti‐CD20 therapies and supports the protective role of interferon.
