Anais da Academia Brasileira de Ciências ()

Insulin-like Growth Factor 1 gene polymorphism and breast cancer risk

  • DANYLO R. COSTA-SILVA,
  • MARIA DA CONCEIÇÃO BARROS-OLIVEIRA,
  • RAFAEL S. BORGES,
  • CLÉCITON B. TAVARES,
  • UMBELINA S. BORGES,
  • FRANCISCO A. ALVES-RIBEIRO,
  • VLADIMIR C. SILVA,
  • BENEDITO B. DA SILVA

DOI
https://doi.org/10.1590/0001-3765201620160169
Journal volume & issue
no. 0

Abstract

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ABSTRACT Insulin-like Growth Factor-1 (IGF-1) gene polymorphism has been associated with an increased risk for breast cancer. IGF-1 is a key regulator of proliferation, cell differentiation and apoptosis. It has important mitogenic and anti-apoptotic activities in normal cells and in breast cancer cells, acting synergistically with estrogen to increase neoplastic cell proliferation. This review aims to present the recent finds of IGF-1 gene polymorphism and its relationship with the risk of breast cancer through following the polymorphic dinucleotide repeat cytosine-adenine (CA) and single nucleotide polymorphisms (SNPs) by searching in the PubMed database publications focused studies published from 2010 to 2015 related to IGF-1 gene polymorphism and breast cancer risk. A growing number of studies support an association between IGF-1 gene polymorphism and breast cancer risk with conflicting results, nevertheless elucidation of the patterns of IGF-1 gene expression may permit characterization of women at high-risk for breast cancer, as well as the development of strategies for early diagnosis and efficient treatment against the disease.

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