Nature Communications (Jun 2019)
CHML promotes liver cancer metastasis by facilitating Rab14 recycle
- Tian-Wei Chen,
- Fen-Fen Yin,
- Yan-Mei Yuan,
- Dong-Xian Guan,
- Erbin Zhang,
- Feng-Kun Zhang,
- Hao Jiang,
- Ning Ma,
- Jing-Jing Wang,
- Qian-Zhi Ni,
- Lin Qiu,
- Jing Feng,
- Xue-Li Zhang,
- Ying Bao,
- Kang Wang,
- Shu-Qun Cheng,
- Xiao-Fan Wang,
- Xiang Wang,
- Jing-Jing Li,
- Dong Xie
Affiliations
- Tian-Wei Chen
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Fen-Fen Yin
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Yan-Mei Yuan
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Dong-Xian Guan
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Erbin Zhang
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Feng-Kun Zhang
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Hao Jiang
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Ning Ma
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Jing-Jing Wang
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Qian-Zhi Ni
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Lin Qiu
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Jing Feng
- Department of General Surgery, Fengxian Hospital Affiliated to Southern Medical University
- Xue-Li Zhang
- Department of General Surgery, Fengxian Hospital Affiliated to Southern Medical University
- Ying Bao
- Department of Surgery, First People’s Hospital Affiliated, Huzhou University
- Kang Wang
- Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University
- Shu-Qun Cheng
- Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University
- Xiao-Fan Wang
- Department of Pharmacology and Cancer Biology, Duke University Medical Center
- Xiang Wang
- Key Laboratory for Translational Medicine, First People’s Hospital Affiliated, Huzhou University
- Jing-Jing Li
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Dong Xie
- CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-019-10364-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Metastasis-associated recurrence is a major cause of poor prognosis in hepatocellular carcinoma. Here, the authors show that expression of choroideremia-like (CHML) is elevated and associates with poor prognosis in hepatocellular carcinoma, and mechanistically CHML promotes metastasis in a Rab14-dependent manner.
