PLoS Genetics (Aug 2010)

The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia.

  • Chao Agnes Hsiung,
  • Qing Lan,
  • Yun-Chul Hong,
  • Chien-Jen Chen,
  • H Dean Hosgood,
  • I-Shou Chang,
  • Nilanjan Chatterjee,
  • Paul Brennan,
  • Chen Wu,
  • Wei Zheng,
  • Gee-Chen Chang,
  • Tangchun Wu,
  • Jae Yong Park,
  • Chin-Fu Hsiao,
  • Yeul Hong Kim,
  • Hongbing Shen,
  • Adeline Seow,
  • Meredith Yeager,
  • Ying-Huang Tsai,
  • Young Tae Kim,
  • Wong-Ho Chow,
  • Huan Guo,
  • Wen-Chang Wang,
  • Sook Whan Sung,
  • Zhibin Hu,
  • Kuan-Yu Chen,
  • Joo Hyun Kim,
  • Ying Chen,
  • Liming Huang,
  • Kyoung-Mu Lee,
  • Yen-Li Lo,
  • Yu-Tang Gao,
  • Jin Hee Kim,
  • Li Liu,
  • Ming-Shyan Huang,
  • Tae Hoon Jung,
  • Guangfu Jin,
  • Neil Caporaso,
  • Dianke Yu,
  • Chang Ho Kim,
  • Wu-Chou Su,
  • Xiao-Ou Shu,
  • Ping Xu,
  • In-San Kim,
  • Yuh-Min Chen,
  • Hongxia Ma,
  • Min Shen,
  • Sung Ick Cha,
  • Wen Tan,
  • Chin-Hao Chang,
  • Jae Sook Sung,
  • Mingfeng Zhang,
  • Tsung-Ying Yang,
  • Kyong Hwa Park,
  • Jeff Yuenger,
  • Chih-Liang Wang,
  • Jeong-Seon Ryu,
  • Yongbing Xiang,
  • Qifei Deng,
  • Amy Hutchinson,
  • Jun Suk Kim,
  • Qiuyin Cai,
  • Maria Teresa Landi,
  • Chong-Jen Yu,
  • Ju-Yeon Park,
  • Margaret Tucker,
  • Jen-Yu Hung,
  • Chien-Chung Lin,
  • Reury-Perng Perng,
  • Paolo Boffetta,
  • Chih-Yi Chen,
  • Kun-Chieh Chen,
  • Shi-Yi Yang,
  • Chi-Yuan Hu,
  • Chung-Kai Chang,
  • Joseph F Fraumeni,
  • Stephen Chanock,
  • Pan-Chyr Yang,
  • Nathaniel Rothman,
  • Dongxin Lin

DOI
https://doi.org/10.1371/journal.pgen.1001051
Journal volume & issue
Vol. 6, no. 8

Abstract

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Genome-wide association studies of lung cancer reported in populations of European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that have achieved genome-wide significance with p-values of 10(-7) or lower. These studies have been performed primarily in cigarette smokers, raising the possibility that the observed associations could be related to tobacco use, lung carcinogenesis, or both. Since most women in Asia do not smoke, we conducted a genome-wide association study of lung adenocarcinoma in never-smoking females (584 cases, 585 controls) among Han Chinese in Taiwan and found that the most significant association was for rs2736100 on chromosome 5p15.33 (p = 1.30 x 10(-11)). This finding was independently replicated in seven studies from East Asia totaling 1,164 lung adenocarcinomas and 1,736 controls (p = 5.38 x 10(-11)). A pooled analysis achieved genome-wide significance for rs2736100. This SNP marker localizes to the CLPTM1L-TERT locus on chromosome 5p15.33 (p = 2.60 x 10(-20), allelic risk = 1.54, 95% Confidence Interval (CI) 1.41-1.68). Risks for heterozygote and homozygote carriers of the minor allele were 1.62 (95% CI; 1.40-1.87), and 2.35 (95% CI: 1.95-2.83), respectively. In summary, our results show that genetic variation in the CLPTM1L-TERT locus of chromosome 5p15.33 is directly associated with the risk of lung cancer, most notably adenocarcinoma.