COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR

Renquan Lu; Xiaobo Hu; Junmei Zhou; Jiajun Sun; Alan Z. Zhu; Xiaofeng Xu; Hui Zheng; Xiang Gao; Xian Wang; Hongchuan Jin; Ping Zhu; Lin Guo

doi:10.1038/ncomms12044

Nature Communications (Jul 2016)

COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR

Renquan Lu,
Xiaobo Hu,
Junmei Zhou,
Jiajun Sun,
Alan Z. Zhu,
Xiaofeng Xu,
Hui Zheng,
Xiang Gao,
Xian Wang,
Hongchuan Jin,
Ping Zhu,
Lin Guo

Affiliations

Renquan Lu: Department of Clinical Laboratory, Fudan University; Department of Oncology, Shanghai Cancer Center, Shanghai Medical School, Fudan University
Xiaobo Hu: Department of Laboratory Medicine, Long Hua Hospital, Shanghai University of TCM
Junmei Zhou: Gerchi Biotech Research Laboratories, 100 Research Park, Zhejiang 314300, China
Jiajun Sun: Department of Clinical Laboratory, Fudan University; Department of Oncology, Shanghai Cancer Center, Shanghai Medical School, Fudan University
Alan Z. Zhu: Gerchi Biotech Research Laboratories, 100 Research Park, Zhejiang 314300, China
Xiaofeng Xu: Department of Clinical Laboratory, Fudan University; Department of Oncology, Shanghai Cancer Center, Shanghai Medical School, Fudan University
Hui Zheng: Department of Clinical Laboratory, Fudan University; Department of Oncology, Shanghai Cancer Center, Shanghai Medical School, Fudan University
Xiang Gao: Department of Clinical Laboratory, Fudan University; Department of Oncology, Shanghai Cancer Center, Shanghai Medical School, Fudan University
Xian Wang: Department of Medical Oncology, Sir Run Run Shaw Hospital
Hongchuan Jin: Department of Medical Oncology, Sir Run Run Shaw Hospital
Ping Zhu: Gerchi Biotech Research Laboratories, 100 Research Park, Zhejiang 314300, China
Lin Guo: Department of Clinical Laboratory, Fudan University; Department of Oncology, Shanghai Cancer Center, Shanghai Medical School, Fudan University

DOI: https://doi.org/10.1038/ncomms12044
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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The corepressor NCoR is required for tamoxifen-mediated ERα-dependent transcriptional repression. Here, the authors show that COPS5 confers tamoxifen-resistance through the degradation of NCOR, the recruitment of the co-activator PCAF to ERα binding sites and the subsequent ERα transcriptional activity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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