Infection and Drug Resistance (Jun 2021)

In vitro Activity of Meropenem-Vaborbactam versus Other Antibiotics Against Carbapenem-Resistant Escherichia coli from Southeastern China

  • Huang N,
  • Chen T,
  • Chen L,
  • Zhang Y,
  • Lin Y,
  • Zheng X,
  • Zhou T,
  • Chen L

Journal volume & issue
Vol. Volume 14
pp. 2499 – 2507

Abstract

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Na Huang,1 Tao Chen,1 Liqiong Chen,2 Ying Zhang,2 Yishuai Lin,2 Xiangkuo Zheng,1 Tieli Zhou,1 Lijiang Chen1 1Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, Zhejiang Province, People’s Republic of China; 2Department of Medical Lab Science, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, 325035, Zhejiang Province, People’s Republic of ChinaCorrespondence: Lijiang Chen; Tieli ZhouDepartment of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, People’s Republic of ChinaTel +86-577-8669-9370; +86-577-86689885Email [email protected]; [email protected]: This study aimed to evaluate the in vitro activity of meropenem-vaborbactam (MVB) against a collection of carbapenem-resistant Escherichia coli (CREC) isolates and to compare the activity with other antibiotics with regard to different separation sites, carbapenem-resistant mechanisms, and sequence types (STs).Methods: A total of 58 CREC strains were used as the experimental strains from the First Affiliated Hospital of Wenzhou Medical University in southeastern China. The minimum inhibitory concentrations of MVB, ceftazidime-avibactam, and tigecycline against all the experimental strains were determined by the microdilution broth method.Results: MVB exhibited higher antimicrobial activity (83% susceptibility) than that of other antibiotics, except for colistin and tigecycline. The susceptibility of CREC strains towards MVB varied with regard to carbapenem-resistant mechanisms and STs, especially in Klebsiella pneumoniae carbapenemase (KPC)-positive isolates and ST8 isolates.Conclusion: MVB exhibited considerably high activity against KPC-producing and ST8 CREC isolates. It has the great potential to be an alternative for the treatment of infections caused by CREC after determining the type of carbapenemase, the susceptibility to MVB and/or STs.Keywords: meropenem-vaborbactam, carbapenem-resistant Escherichia coli, in vitro activity, KPC-producing, ST8

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