Nature Communications (Jun 2019)

Live imaging screen reveals that TYRO3 and GAK ensure accurate spindle positioning in human cells

  • Benita Wolf,
  • Coralie Busso,
  • Pierre Gönczy

DOI
https://doi.org/10.1038/s41467-019-10446-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

Correct spindle positioning is critical for cell division but the full set of proteins regulating this is unclear. Here, with a live imaging siRNA-based screen in human cells, the authors identify 16 candidates required for this process, 11 of which were previously unassociated with such a function, including TYRO3 and GAK.