Nature Communications (Mar 2019)

Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes

  • Peiman Shooshtarizadeh,
  • Anne Helness,
  • Charles Vadnais,
  • Nelleke Brouwer,
  • Hugues Beauchemin,
  • Riyan Chen,
  • Halil Bagci,
  • Frank J. T. Staal,
  • Jean-François Coté,
  • Tarik Möröy

DOI
https://doi.org/10.1038/s41467-019-09273-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

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Gfi1b regulates cellularity of haematopoietic stem cells (HSCs) and megakaryocytes (MKs) as well as spreading of MKs on matrix. Here the authors show that Gfi1b regulates this behaviour by recruiting LSD1 and β-catenin to Wnt/β-catenin signalling targets.