DEMONSTRATION OF HETEROARYLMETHANE OXIDATION IN A BENZIMIDAZOLE DERIVATIVE WITH THE USE OF UV SPECTROPHOTOMETRY AND X-RAY DIFFRACTION

Abstract

In this work, we present the synthesis of a copper complex of 1-benzyl-2-[(5-methyl-isoxazol-3-yl)methyl]-benzimidazole, by using simultaneously UV spectrophotometry and X-ray diffraction. It has been possible for us to highlight an original oxidation of benzylbenzimidazole group in such complex leading to ketone. A kinetic study carried out by UV spectrophotometry shows well that the oxidation reaction proceeds according to the first-order kinetic law: K = 9.4×10-4 s-1 and t½ = 12.4 min.

Keywords

• complexation
• functionalised benzimidazole
• kinetic
• UV spectrophotometry
• X-ray study