Memorias do Instituto Oswaldo Cruz (Mar 2016)

CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study

  • Erinaldo Ubirajara Damasceno dos Santos,
  • Géssica Dayane Cordeiro de Lima,
  • Micheline de Lucena Oliveira,
  • Sandra de Andrade Heráclio,
  • Hildson Dornelas Angelo da Silva,
  • Sergio Crovella,
  • Maria de Mascena Diniz Maia,
  • Paulo Roberto Eleutério de Souza/

DOI
https://doi.org/10.1590/0074-02760150367
Journal volume & issue
Vol. 111, no. 3
pp. 174 – 180

Abstract

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Polymorphisms in chemokine receptors play an important role in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer (CC). Our study examined the association of CCR2-64I (rs1799864) andCCR5-Δ32 (rs333) polymorphisms with susceptibility to develop cervical lesion (CIN and CC) in a Brazilian population. The genotyping of 139 women with cervical lesions and 151 women without cervical lesions for the CCR2-64I and CCR5-Δ32 polymorphisms were performed using polymerase chain reaction-restriction fragment length polymorphism. The individuals carrying heterozygous or homozygous genotypes (GA+AA) for CCR2-64I polymorphisms seem to be at lower risk for cervical lesion [odds ratio (OR) = 0.37, p = 0.0008)]. The same was observed for the A allele (OR = 0.39, p = 0.0002), while no association was detected (p > 0.05) with CCR5-Δ32 polymorphism. Regarding the human papillomavirus (HPV) type, patients carrying the CCR2-64Ipolymorphism were protected against infection by HPV type 16 (OR = 0.35, p = 0.0184). In summary, our study showed a protective effect ofCCR2-64I rs1799864 polymorphism against the development of cervical lesions (CIN and CC) and in the susceptibility of HPV 16 infection.

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