Molecules (Apr 2011)

Three New Oblongolides from Phomopsis sp. XZ-01, an Endophytic Fungus from Camptotheca acuminate

  • Hai Feng Chen,
  • Xiao Kun Zhang,
  • Quan Cheng Chen,
  • Zhi Yu Hu,
  • Xiang Lin,
  • Ting Lin,
  • Guang Hui Wang,
  • Yang Xu

DOI
https://doi.org/10.3390/molecules16043351
Journal volume & issue
Vol. 16, no. 4
pp. 3351 – 3359

Abstract

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Four new metabolites, including three new oblongolides named C1, P1, and X1 (1-3) and 6-hydroxyphomodiol (10), along with eight known compounds – oblongolides B (4), C (5), D (6), O (7), P (8) and U (9), (3R,4aR,5S,6R)-6-hydroxy-5-methylramulosin (11), and (3R)-5-methylmellein (12) – were isolated from the endophytic fungal strain Phomopsis sp. XZ-01 of Camptotheca acuminate. Their structures were elucidated by spectroscopic analyses, including 1H- and 13C-NMR, 2D NMR (HSQC, HMBC, 1H-1H COSY and NOESY) and HR-FT-MS. Cytotoxic activities of these compounds were evaluated. Some of them showed weak selective activities.

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