Respiratory Medicine Case Reports (Jan 2020)
Combination treatment of short-course systemic corticosteroid and favipiravir in a successfully treated case of critically ill COVID-19 pneumonia with COPD
- Hideki Inoue,
- Megumi Jinno,
- Shin Ohta,
- Yasunari Kishino,
- Tomoko Kawahara,
- Hatsuko Mikuni,
- Haruna Sato,
- Mayumi Yamamoto,
- Yoko Sato,
- Chisato Onitsuka,
- Yuiko Goto,
- Hitoshi Ikeda,
- Hiroki Sato,
- Tomoki Uno,
- Yoshitaka Uchida,
- Tomoyuki Kimura,
- Yoshito Miyata,
- Kuniaki Hirai,
- Tetsuya Homma,
- Yoshio Watanabe,
- Sojiro Kusumoto,
- Shintaro Suzuki,
- Issei Tokimatsu,
- Akihiko Tanaka,
- Hironori Sagara
Affiliations
- Hideki Inoue
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan; Corresponding author. 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
- Megumi Jinno
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Shin Ohta
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Yasunari Kishino
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Tomoko Kawahara
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Hatsuko Mikuni
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Haruna Sato
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Mayumi Yamamoto
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Yoko Sato
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Chisato Onitsuka
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Yuiko Goto
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Hitoshi Ikeda
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Hiroki Sato
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Tomoki Uno
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Yoshitaka Uchida
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Tomoyuki Kimura
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Yoshito Miyata
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Kuniaki Hirai
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Tetsuya Homma
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Yoshio Watanabe
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Sojiro Kusumoto
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Shintaro Suzuki
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Issei Tokimatsu
- Division of Infectious Diseases, Department of Medicine, Showa University School of Medicine, Japan
- Akihiko Tanaka
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Hironori Sagara
- Division of Respiratory Medicine and Allergology, Department of Medicine, Showa University School of Medicine, Japan
- Journal volume & issue
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Vol. 31
p. 101200
Abstract
Use of systemic corticosteroids for the treatment for coronavirus disease 2019 (COVID-19) among chronic obstructive pulmonary disease (COPD) patients is not well described. A 58-year-old man with fever and progressive dyspnea was admitted to the Showa University Hospital, and showed severe respiratory failure which needed mechanical ventilation. His chest computed tomography scanning showed emphysema and bilateral ground-glass opacity caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. He received 30 mg prednisolone for five days with antiviral drug of favipiravir, and was successfully extubated on day five. A SARS-CoV-2 polymerase chain reaction (PCR) test became negative on day 15. He was discharged on day 21. Serum IgM and IgG antibodies against SARS-CoV-2 converted to positive on day 7 and they kept positive on day 54 for both IgM and IgG. Combination treatment of short-course systemic corticosteroid and favipiravir might improve the prognosis for critically ill COVID-19 pneumonia with COPD without negative influence on viral clearance or antibody production.
