Antibiotics (Sep 2020)

Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance

  • Matteo Bassetti,
  • Antonio Vena,
  • Chiara Sepulcri,
  • Daniele Roberto Giacobbe,
  • Maddalena Peghin

DOI
https://doi.org/10.3390/antibiotics9090632
Journal volume & issue
Vol. 9, no. 9
p. 632

Abstract

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The rising incidence of bloodstream infections (BSI) due to Gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) has been recognized as a global emergency. The aim of this review is to provide a comprehensive assessment of the mechanisms of antibiotic resistance, epidemiology and treatment options for BSI caused by GNB with DTR, namely extended-spectrum Beta-lactamase-producing Enterobacteriales; carbapenem-resistant Enterobacteriales; DTR Pseudomonas aeruginosa; and DTR Acinetobacter baumannii.

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