Nature Communications (Apr 2020)

FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku

  • Hanyong Jin,
  • Boeun Lee,
  • Yongyang Luo,
  • Yuri Choi,
  • Eui-Hwan Choi,
  • Hong Jin,
  • Kee-Beom Kim,
  • Sang Beom Seo,
  • Yong-Hak Kim,
  • Hyung Ho Lee,
  • Keun Pil Kim,
  • Kangseok Lee,
  • Jeehyeon Bae

DOI
https://doi.org/10.1038/s41467-020-15748-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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The Ku complex, formed by XRCC5/6 heterodimer, binds to double strand break (DSB) ends, initiating non homologous end joining (NHEJ) and preventing homologous recombination (HR). Here, the authors reveal that FOXL2, a forkhead family transcriptional factor, directs DSB repair pathway choice by acetylation-dependent binding to Ku.