The Effects of Mild Forced Treadmill Exercise and GABA-B Agonist on Locomotor Activity and Anxiety-Behavior in Rats with Striatum Dysfunction

Abstract

Background. the basal ganglia’s circuit dysfunction has a major role in a range of movement disorders. Some evidence has shown that exercise can improve performance, especially locomotor activity after brain injuries. There was currently insufficient information to define the impacts of intensity, duration, and frequency of different exercises. Objectives. in this study, we examine the role of mild forced treadmill exercise and GABA-B agonist on locomotor activity and anxiety-behavior dysfunction of ibotenic acid injection in striatum. Methods. forty male Wistar rats were randomly split into five groups. The animals received ibotenic acid infusions into striatum bilaterally. Locomotor activities of rats were assessed by open-field apparatus. Results. Our results showed that mild forced treadmill exercise and GABA-B could significantly increase distance in open field and decrease anxiety-behavior in treadmill and drug groups than lesion group (P=0.008 and P=0.001 respectively). Conclusion. There is no significant difference between treadmill and drug groups. So, mild forced treadmill exercise and baclofen could improve motor dysfunction of lesion by ibotenic acid injection in striatum and anxiety-behavior.

Keywords

• striatum
• ibotenic acid
• spatial memory
• treadmill exercise
• locomotor activity