Nature Communications (Aug 2018)
CTD-dependent and -independent mechanisms govern co-transcriptional capping of Pol II transcripts
Abstract
The co-transcriptional capping of transcripts synthesized by RNA Pol II is substantially more efficient than capping of free RNA, a process that has been shown to depend on CTD phosphorylation. Here the authors demonstrate that a CTD-independent mechanism functions in parallel with CTD-dependent processes to ensure efficient capping.