Nature Communications (Aug 2018)

CTD-dependent and -independent mechanisms govern co-transcriptional capping of Pol II transcripts

  • Melvin Noe Gonzalez,
  • Shigeo Sato,
  • Chieri Tomomori-Sato,
  • Joan W. Conaway,
  • Ronald C. Conaway

DOI
https://doi.org/10.1038/s41467-018-05923-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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The co-transcriptional capping of transcripts synthesized by RNA Pol II is substantially more efficient than capping of free RNA, a process that has been shown to depend on CTD phosphorylation. Here the authors demonstrate that a CTD-independent mechanism functions in parallel with CTD-dependent processes to ensure efficient capping.