Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial

• Eva Skovlund,
• Rune Haaverstad,
• Henrik Zetterberg,
• Jorunn L Helbostad,
• Rolf Busund,
• Johan Raeder,
• Theis Tønnessen,
• Torgeir Bruun Wyller,
• Melanie R Simpson,
• Nils Kristian Skjærvold,
• Bjørn Erik Neerland,
• Svein Aslak Landsverk,
• Ieva Martinaityte,
• Hilde Margrethe Norum,
• Geir Selbaek,
• Elisabeth Skaar,
• Arjen JC Slooter,
• Øyvind Sverre Svendsen,
• Alexander Wahba

Affiliations

Eva Skovlund

Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Trondheim, Trøndelag, Norway

Rune Haaverstad

Department of Heart Disease, Haukeland University Hospital, Bergen, Norway

Henrik Zetterberg

Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK

Jorunn L Helbostad

Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway

Rolf Busund

Institute of Clinical Medicine, The Arctic University of Norway, UiT, Tromsø, Norway

Johan Raeder

Department of Anaesthesiology, Oslo University Hospital, Oslo, Norway

Theis Tønnessen

6 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

Torgeir Bruun Wyller

4 Oslo Delirium Research Group, Department of Geriatric Medicine, University of Oslo, Oslo, Norway

Melanie R Simpson

Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway

Nils Kristian Skjærvold

Department of Anesthesiology and Intensive Care Medicine, St. Olav`s University Hospital, Trondheim, Norway

Bjørn Erik Neerland

Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway

Svein Aslak Landsverk

Department of Anaesthesiology, Oslo University Hospital, Oslo, Norway

Ieva Martinaityte

Institute of Clinical Medicine, UiT The Artic University of Norway, Tromsø, Norway

Hilde Margrethe Norum

Department of Anaesthesiology, Oslo University Hospital, Oslo, Norway

Geir Selbaek

Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway

Elisabeth Skaar

Department of Heart Disease, Haukeland University Hospital, Bergen, Norway

Arjen JC Slooter

Department of Intensive Care Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands

Øyvind Sverre Svendsen

Department of Anesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway

Alexander Wahba

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway