Nature Communications (Mar 2018)

The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development

  • Maria A. Schumacher,
  • Chris D. den Hengst,
  • Matthew J. Bush,
  • T. B. K. Le,
  • Ngat T. Tran,
  • Govind Chandra,
  • Wenjie Zeng,
  • Brady Travis,
  • Richard G. Brennan,
  • Mark J. Buttner

DOI
https://doi.org/10.1038/s41467-018-03576-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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BldC regulates the onset of differentiation in Streptomycetes by a yet unknown molecular mechanism. Using a combination of structural, biochemical and in vivo approaches, the authors show that BldC controls the transcription of several developmental regulators and unravel its DNA binding mode.