Nature Communications (Mar 2018)
The MerR-like protein BldC binds DNA direct repeats as cooperative multimers to regulate Streptomyces development
Abstract
BldC regulates the onset of differentiation in Streptomycetes by a yet unknown molecular mechanism. Using a combination of structural, biochemical and in vivo approaches, the authors show that BldC controls the transcription of several developmental regulators and unravel its DNA binding mode.