Syntehsis and evaluation of Gd3+ -Trp-PLGA as novel nanosized MR tumor imaging candidate

Abstract

Objective(s): Early detection of cancer can significantly increase the likelihood of successful treatment, and imaging assay can have a significant impact on cancer diagnosis. Although gadolinium compounds are used as a contrast agent in MRI, this substance has side effects and disadvantages. Nanotechnology has so far had a significan impact on medical imaging methods, especially MRI, nanoparticles are contrast enhancers that Each with its characteristics have increased the quality of images and reduced toxicity.Materials and Methods: In this study, a novel nano-conjugate based PLGA-tryptophan was synthesized and loaded with Gd3+ for using it as a potential MR imaging contrast agent to overcome the previous disadvantage. In vitro cell toxicity, cellular uptake and MR imaging parameters of the prepared nanoconjugate were investigated ,Results: The results showed no in vivo toxicity plus flowcytometry assays, good cellular uptake and large longitudinal (r1).Conclusion: Convenient features of the nano-probe indicate that it is a promising agent to use as a MR imaging agent.

Keywords

• cell toxicity
• gd3+
• mr imaging
• plga
• trp
• relaxivity times