Indian Journal of Dermatology (Jan 2023)

Dupilumab-associated sezary syndrome

  • Austin Hamp,
  • Jamie Hanson,
  • Albert Alhatem,
  • Robert A Schwartz

DOI
https://doi.org/10.4103/ijd.ijd_580_22
Journal volume & issue
Vol. 68, no. 4
pp. 459 – 462

Abstract

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Dupilumab is a monoclonal antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13), approved for the treatment of adults with moderate-to-severe atopic dermatitis (AD). While recent reports have described cases of new-onset mycosis fungoides (MF) following treatment with dupilumab for AD, to our knowledge only one patient has been delineated with the progression to SS. We present an additional case of a patient who was diagnosed with SS following treatment with dupilumab for adult-onset AD and asthma. We examine SS as a possible side effect of dupilumab while also discussing management and theories to explain this phenomenon.

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