Inflammation and Regeneration (Dec 2022)

Quercetin enhances survival and axonal regeneration of motoneurons after spinal root avulsion and reimplantation: experiments in a rat model of brachial plexus avulsion

  • Yanfeng Huang,
  • Xie Zhang,
  • Qionghui Huang,
  • Yaoxing Dou,
  • Chang Qu,
  • Qingqing Xu,
  • Qiuju Yuan,
  • Yan-Fang Xian,
  • Zhi-Xiu Lin

DOI
https://doi.org/10.1186/s41232-022-00245-3
Journal volume & issue
Vol. 42, no. 1
pp. 1 – 16

Abstract

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Highlights • Quercetin (QCN) promotes motoneuron survival and accelerates axonal regeneration after brachial plexus root avulsion/re-implantation in rats. • QCN improves motor function recovery of the forelimb. • QCN exhibits neuroprotective effects via inhibiting neuroinflammation and upregulating the neurotrophins. • QCN alleviates the avulsion-induced oxidative damage in rats. • QCN inhibits the avulsion-induced neuronal apoptosis in rats. • QCN modulates Nrf2/HO-1 and neurotrophin/Akt/MAPK signaling pathways.

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