Clinical and pathological features of infant and young children brain tumors: single center report of 100 cases

Abstract

Objective To investigate the special clinical manifestations, pathological spectrum and locations of infant and young children (0-3 years old) brain tumors that differed from those of the older children population (4-18 years old). Methods Children ( 100 mm in diameter. The overall survival (OS) rate in low⁃grade (WHOⅠ-Ⅱ) tumor group was significantly higher than that in high⁃grade (WHOⅢ-Ⅳ) tumor group (P = 0.000). Conclusions Brain tumors in infants and young children had special pathological spectrum and clinical manifestations being different from the older children tumor population. The prognosis of low⁃grade glioma in infants and young children was good and had the characteristics of chronic disease. Malignant brain tumors, including rare embryonal tumors, were prone to relapse and multiple metastases across the central nervous system. The young children couldn't suffer radiotherapy, and at the mean time, the choice and effect of chemotherapy were quite limited. To improve the quality of life and the prognosis of infants and young children with brain tumors required more extensive multi⁃disciplinary cooperation. DOI：10.3969/j.issn.1672⁃6731.2019.12.011

Keywords

• brain neoplasms
• infant
• pathology
• prognosis