Department of Pediatrics, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil
Thais Moura Guimarães
Departamento de Psicobiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil
Vânia D'Almeida
Department of Pediatrics, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil
Dalva Poyares
Departamento de Psicobiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil
Cibele Dal-Fabbro
Research Center of Le Centre Intégré Universitaire de Santé et de Services Sociaux (CIUSSS) du Nord-de-l'île-de-Montréal, Université de Montreal, Montreal, Quebec, Canada
Sergio Tufik
Departamento de Psicobiologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil
Gustavo A. Moreira
Department of Pediatrics, Escola Paulista de Medicina, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brazil
Myasthenia gravis (MG) is a chronic autoimmune disease characterized by progressive weakness and skeletal muscle fatigue due to the destruction of acetylcholine receptors, causing an abnormality in the synaptic junction between innervation and muscle fibers. The treatment of patients with MG and obstructive sleep apnea (OSA) is positive pressure in the airway; however, the lack of adherence to the protocol can lead to increased morbidity. A known alternative treatment for OSA is the mandibular advancement device (MAD). The objective of the present report is to describe an emblematic case of a 50-year-old male patient with MG with sleep complaints and documented OSA, and his response to different treatment approaches.
