The Egyptian Journal of Bronchology (Jan 2022)

The emerging therapeutic role of some pharmacological antidotes in management of COVID-19

  • Doaa M. El Shehaby,
  • Marwa Kh. Mohammed,
  • Noha Esmael Ebrahem,
  • Mariam M. Abd El-Azim,
  • Islam G. Sayed,
  • Sarah A. Eweda

DOI
https://doi.org/10.1186/s43168-021-00105-7
Journal volume & issue
Vol. 16, no. 1
pp. 1 – 12

Abstract

Read online

Abstract Background A novel RNA coronavirus was identified in January 2020 as the cause of a pneumonia epidemic affecting the city of Wuhan; it rapidly spread across China. Aim of the review The aim is to discuss the potential efficacy of some pharmacologically known pharmacological antidotes (N-acetylcysteine; hyperbaric oxygen; deferoxamine; low-dose naloxone) for the management of COVID-19-associated symptoms and complications. Method An extensive search was accomplished in Medline, Embase, Scopus, Web of Science, and Central databases until the end of April, 2021. Four independent researchers completed the screening, and finally, the associated studies were involved. Conclusion The current proof hinders the experts for suggesting the proper pharmacological lines of treatment of COVID-19. Organizations, for example, WHO, should pursue more practical actions and design well-planned clinical trials so that their results may be used in the treatment of future outbreaks.

Keywords