Frontiers in Medicine (Jan 2025)

Chronic osteomyelitis with pathological fracture induced by Mycoplasma hominis infection: a case report and review of the literature

  • Ling-Na Zhu,
  • Wen-Bin Shen,
  • Xiao-Yan Zou,
  • Jiang-Cheng Zuo,
  • Ning Xiao

DOI
https://doi.org/10.3389/fmed.2025.1510753
Journal volume & issue
Vol. 12

Abstract

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Mycoplasma hominis, commonly residing in the genitourinary tract, can cause rare extragenital infections, especially in immunocompromised individuals. This report details a case of chronic osteomyelitis with a pathological femur fracture in a 79-year-old woman. Despite a history of bone tuberculosis, the infection was identified as Mycoplasma hominis through culture and mass spectrometry, highlighting the diagnostic challenges due to the organism’s lack of a cell wall. This case underscores the necessity for advanced diagnostic methods and awareness of Mycoplasma hominis in non-urogenital infections.

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