Nature Communications (Dec 2017)
Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase
- Sina Reckel,
- Charlotte Gehin,
- Delphine Tardivon,
- Sandrine Georgeon,
- Tim Kükenshöner,
- Frank Löhr,
- Akiko Koide,
- Lena Buchner,
- Alejandro Panjkovich,
- Aline Reynaud,
- Sara Pinho,
- Barbara Gerig,
- Dmitri Svergun,
- Florence Pojer,
- Peter Güntert,
- Volker Dötsch,
- Shohei Koide,
- Anne-Claude Gavin,
- Oliver Hantschel
Affiliations
- Sina Reckel
- Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL)
- Charlotte Gehin
- Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL)
- Delphine Tardivon
- Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL)
- Sandrine Georgeon
- Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL)
- Tim Kükenshöner
- Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL)
- Frank Löhr
- Institute of Biophysical Chemistry, Goethe University Frankfurt
- Akiko Koide
- Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center
- Lena Buchner
- Institute of Biophysical Chemistry, Goethe University Frankfurt
- Alejandro Panjkovich
- European Molecular Biology Laboratory (EMBL), Hamburg Outstation
- Aline Reynaud
- Protein Crystallography Core Facility, School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL)
- Sara Pinho
- Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL)
- Barbara Gerig
- Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL)
- Dmitri Svergun
- European Molecular Biology Laboratory (EMBL), Hamburg Outstation
- Florence Pojer
- Protein Crystallography Core Facility, School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL)
- Peter Güntert
- Institute of Biophysical Chemistry, Goethe University Frankfurt
- Volker Dötsch
- Institute of Biophysical Chemistry, Goethe University Frankfurt
- Shohei Koide
- Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center
- Anne-Claude Gavin
- Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL)
- Oliver Hantschel
- Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL)
- DOI
- https://doi.org/10.1038/s41467-017-02313-6
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
The Bcr-Abl tyrosine kinases p210 and p190 are linked to different leukemias and differ by the Dbl homology (DH) and Pleckstrin-homology (PH) domains. Here the authors characterize structures of the Bcr-Abl p210 DH and PH domains and find that the PH domain is important for the cellular localization and signaling network of p210.
