Research progress of RhoGTPase activating protein in epithelial-mesenchymal transition

XU Qian, DUAN Hua, GAN Lu, LIU Qiwei

doi:10.16352/j.issn.1001-6325.2023.02.301

Jichu yixue yu linchuang (Feb 2023)

Research progress of RhoGTPase activating protein in epithelial-mesenchymal transition

XU Qian, DUAN Hua, GAN Lu, LIU Qiwei

Affiliations

XU Qian, DUAN Hua, GAN Lu, LIU Qiwei: Department of Gynecology Minimally Invasive Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100006, China

DOI: https://doi.org/10.16352/j.issn.1001-6325.2023.02.301
Journal volume & issue: Vol. 43, no. 2
pp. 301 – 305

Abstract

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Epithelial-mesenchymal transition (EMT) is a process by which epithelial cells undergo morphological changes to gain a mesenchymal cell phenotype and migratory properties. As a class of negative regulators of RhoGTPases, RhoGTPase activating proteins(RhoGAP) can bridge between cell surface receptors and cellular actin cytoskeleton during EMT procedure, which may influence cancer cell transition and outcome of fibrotic diseases and may help search for anti-tumor and anti-fibrotic managements.

rhogtpase activating protein|epithelial-mesenchymal transition|actin cytoskeleton|metastasis|fibrotic diseases

Published in Jichu yixue yu linchuang

ISSN: 1001-6325 (Print)
Publisher: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Country of publisher: China
LCC subjects: Medicine
Website: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/1001-6325/home.shtml

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